Titin is a Target of Matrix Metalloproteinase-2
نویسندگان
چکیده
منابع مشابه
Molecular Cardiology Titin is a Target of Matrix Metalloproteinase-2 Implications in Myocardial Ischemia/Reperfusion Injury
In the fall of 2006 I joined the Department of Pharmacology, University of Alberta as a PhD graduate student under the supervision of Dr. Richard Schulz. The Schulz lab studies ischemic and inflammatory heart diseases and investigates the role of specific molecules contributing to oxidative stress injury of the heart. Being in the first laboratory to discover that matrix metalloproteinase (MMP)...
متن کاملTitin is a target of matrix metalloproteinase-2: implications in myocardial ischemia/reperfusion injury.
BACKGROUND Titin is the largest mammalian (≈3000 to 4000 kDa) and myofilament protein that acts as a molecular spring in the cardiac sarcomere and determines systolic and diastolic function. Loss of titin in ischemic hearts has been reported, but the mechanism of titin degradation is not well understood. Matrix metalloproteinase-2 (MMP-2) is localized to the cardiac sarcomere and, on activation...
متن کاملExpression of Matrix Metalloproteinase-2 and -9 in Meningioma
Background: Meningioma is one of the most common tumors of the central nervous system. It was shown that meningioma had up-regulated expression of Matrix Metalloproteinases (MMPs) that involved in cell growth, angiogenesis and metastasis. Objectives: The aim of the study was the assessment of serum MMP-2 and -9 levels in patients with different grades of meningioma. Materials & Me...
متن کاملMatrix metalloproteinase-2 is expressed in melanoma-associated spongiform scleropathy.
PURPOSE To correlate the expression of matrix metalloproteinases (MMPs) with melanoma-associated spongiform scleropathy (MASS) and scleral tumor invasion in eyes with uveal melanoma. METHODS Eleven specimens with MASS and 11 eyes without MASS were investigated. Sections were examined for MMP-1, -2, -9, and -13 mRNA expression by in situ hybridization with (35)S-radiolabeled riboprobes. Immuno...
متن کاملPeroxynitrite-induced myocardial injury is mediated through matrix metalloproteinase-2.
OBJECTIVES Peroxynitrite (ONOO(-)) mediates in part both ischemia-reperfusion and pro-inflammatory cytokine-induced injury to the heart. As oxidants like ONOO(-) are known to activate matrix metalloproteinases (MMPs), we examined whether they play a role in the detrimental action of ONOO(-) in isolated perfused rat hearts. METHODS Hearts were isolated from Sprague-Dawley rats and perfused ret...
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ژورنال
عنوان ژورنال: Circulation
سال: 2010
ISSN: 0009-7322,1524-4539
DOI: 10.1161/circulationaha.109.930222